Intraoperative Radiation Therapy Market Size, Share & Forecast (2025-2035)

Key Market Highlights

Intraoperative Radiation Therapy Market Size Was Valued at USD 133.07 Million in 2024, and is Projected to Reach USD 292.92 Million by 2035, Growing at a CAGR of 8.21% from 2025-2035.

• Market Size in 2024: USD 133.07 Million
• Projected Market Size by 2035: USD 292.92 Million
• CAGR (2025–2035): 8.21%
• Leading Market in 2024: North America
• Fastest-Growing Market: Asia-Pacific
• By Technology: The Intraoperative Electron Radiation Therapy (IOERT) segment is anticipated to lead the market by accounting for 36.24% of the market share throughout the forecast period.
• By Application: The Breast Cancer segment is expected to capture 25.31% of the market share, thereby maintaining its dominance over the forecast period.
• By Region: North America region is projected to hold 29.65% of the market share during the forecast period.
• Active Players: Carl Zeiss Meditec AG (Germany), IntraOp Medical Corporation (USA), Ariane Medical Systems Ltd (United Kingdom), Eckert & Ziegler (Germany), GMV Innovating Solutions (Spain), Sensus Healthcare Inc. (USA), Sordina IORT Technologies (Italy), Isoray Inc. (USA), Accuray Incorporated (USA), Ion Beam Applications S.A. (Belgium), Brainlab AG (Germany), Zap Surgical Systems Inc. (USA), Surgiceye GmbH (Germany), ViewRay Inc.  (USA), and Other Active Players

Intraoperative Radiation Therapy Market Synopsis:

The Intraoperative Radiation Therapy (IORT) market involves the technology, equipment (like mobile linear accelerators), and services for delivering a single, high dose of radiation directly to a tumour site during surgery, targeting remaining cancer cells while sparing healthy tissue, used mainly for breast, colorectal, pancreatic, and brain cancers, reducing overall treatment time and improving local control, with market growth driven by rising cancer cases and tech adoption

Intraoperative Radiation Therapy Market Dynamics and Trend Analysis:

Intraoperative Radiation Therapy Market Growth Driver- Rising Demand for Precision Oncology and Single-Session Cancer Treatment

• The growth of the Intraoperative Radiation Therapy (IORT) market is mainly driven by the rising global cancer burden and increasing demand for precise and efficient cancer treatments. IORT allows doctors to deliver a high dose of radiation during surgery, which reduces damage to healthy tissues and lowers the risk of cancer recurrence.
•  The growing adoption of breast-conserving surgeries, advancements in portable radiation systems, and improved treatment planning software also support market growth. In addition, shorter treatment duration, better patient comfort, and expanding oncology infrastructure in emerging economies are encouraging hospitals to adopt IORT technologies globally. ?

Intraoperative Radiation Therapy Market Limiting Factor- High Capital Investment and Limited Clinical Availability

• A major limiting factor for the Intraoperative Radiation Therapy (IORT) market is the high cost of equipment and infrastructure. IORT systems, including mobile accelerators and shielding requirements, require significant upfront investment, which restricts adoption in small and mid-sized hospitals. In addition, the need for specialized surgical and radiation oncology teams limits widespread use.
• Limited reimbursement policies in some regions and lack of trained professionals further slow market expansion. Moreover, IORT is suitable only for selected cancer cases, which reduces patient volume. These factors collectively restrain the rapid penetration of IORT technology, especially in developing healthcare markets

Intraoperative Radiation Therapy Market Expansion Opportunity- Expansion of Portable IORT Systems in Emerging Cancer Care Markets

• A key expansion opportunity in the Intraoperative Radiation Therapy (IORT) market lies in the growing adoption of portable and compact IORT systems, especially in emerging economies. Developing countries are investing heavily in oncology infrastructure and seeking cost-effective technologies that improve treatment efficiency. Portable IORT systems require less shielding and integrate easily into existing operating rooms, making them attractive for new cancer centers.
•  In addition, increasing awareness of single-session radiotherapy benefits, rising breast cancer surgeries, and supportive clinical outcomes are encouraging hospitals to adopt IORT, creating strong growth potential across Asia Pacific, Latin America, and the Middle East.

Intraoperative Radiation Therapy Market Challenge and Risk- Clinical Standardization Gaps and Adoption Risk

• One of the key challenges and risks in the Intraoperative Radiation Therapy (IORT) market is the lack of uniform clinical guidelines and standard treatment protocols across regions. Differences in surgeon experience, radiation dosing practices, and patient selection can affect treatment outcomes. Inconsistent long-term clinical data for certain cancer types also creates hesitation among healthcare providers.
• Additionally, operational risks such as equipment downtime, workflow disruption during surgery, and dependence on skilled multidisciplinary teams can limit adoption. These factors increase clinical and operational uncertainty, making hospitals cautious about investing in IORT technologies despite their potential benefits.

Intraoperative Radiation Therapy Market Trend- Shift Toward Portable, Precision-Focused Intraoperative Cancer Therapy

• The Intraoperative Radiation Therapy (IORT) market is witnessing a clear trend toward portable and compact radiation systems that can be easily used within operating rooms. Hospitals are increasingly adopting IORT for breast-conserving surgeries due to shorter treatment time and improved patient convenience. There is also growing integration of advanced software and real-time treatment planning tools to enhance accuracy and safety.
• In addition, rising focus on precision oncology, combined with multidisciplinary surgical-radiation collaboration, is shaping clinical practice. Emerging markets are showing increased interest as healthcare infrastructure improves and awareness of single-session radiotherapy benefits continues to grow.

Intraoperative Radiation Therapy Market Segment Analysis:

Intraoperative Radiation Therapy Market is segmented based on Technology, Application, Product, and Region

By Technology, Electron Intraoperative Radiation Therapy (Electron IORT) segment is expected to dominate the market with around 36.24% share during the forecast period.

• Electron Intraoperative Radiation Therapy (Electron IORT) is the most commonly used technology segment because it is clinically proven, precise, and versatile. It delivers a high radiation dose directly to the tumour bed during surgery while protecting nearby healthy tissues. Electron IORT is widely used across multiple cancers such as breast, colorectal, and pancreatic cancer, making it suitable for many hospitals.
• The availability of mobile linear accelerators, strong long-term clinical evidence, and surgeon familiarity further support its adoption. In addition, Electron IORT integrates well into existing surgical workflows, which increases its acceptance in advanced cancer centers worldwide.

By Application, Breast Cancer is expected to dominate with close to 25.31% market share during the forecast period.

• By application, breast cancer is the most common and dominant segment in the Intraoperative Radiation Therapy (IORT) market. From a research analyst perspective, this is mainly due to the high global incidence of breast cancer and the growing preference for breast-conserving surgery.
• IORT allows radiation to be delivered immediately after tumor removal, directly to the affected area, reducing damage to healthy tissue. It also shortens overall treatment time and, in some cases, replaces weeks of external radiotherapy. Strong clinical evidence, patient convenience, better cosmetic outcomes, and support from oncologists and surgeons have made breast cancer the leading application for IORT worldwide.

Intraoperative Radiation Therapy Market Regional Insights:

North America region is estimated to lead the market with around 29.65% share during the forecast period.

• North America is leading the Intraoperative Radiation Therapy (IORT) market due to its advanced healthcare infrastructure and early adoption of innovative cancer treatments. The region has a high number of well-equipped hospitals and specialized cancer centers that can support IORT systems.
• Strong clinical research activity, availability of skilled surgeons and radiation oncologists, and wide acceptance of breast-conserving surgeries further drive adoption. In addition, favorable reimbursement policies and strong presence of leading IORT technology manufacturers support market growth. High cancer prevalence and continuous investment in precision oncology make North America the most dominant region in the IORT market.

Intraoperative Radiation Therapy Market Active Players:)

• Carl Zeiss Meditec AG (Germany)
• IntraOp Medical Corporation (USA)
• Ariane Medical Systems Ltd (United Kingdom)
• Eckert & Ziegler (Germany)
• GMV Innovating Solutions (Spain)
• Sensus Healthcare Inc. (USA)
• Sordina IORT Technologies (Italy)
• Isoray Inc. (USA)
• Accuray Incorporated (USA)
• Ion Beam Applications S.A. (Belgium)
• Brainlab AG (Germany)
• Zap Surgical Systems Inc. (USA)
• Surgiceye GmbH (Germany)
• ViewRay Inc.  (USA)
• Other Active Players

Key Industry Developments in the Intraoperative Radiation Therapy Market:

• In April 2025, Carl Zeiss Meditec received FDA 510(k) clearance for the new ZEISS INTRABEAM 700, an advanced robotic-assisted intraoperative radiotherapy platform designed to improve precision, workflow efficiency, and connectivity in cancer surgery, including neuro-oncology and breast cancer IORT
• In May 2023, IntraOp announced the world’s first Phase II randomized trial comparing FLASH electron radiotherapy to conventional radiotherapy using its Mobetron system, supporting advanced IORT research and clinical evidence.

Intraoperative Radiation Therapy Overview

• Intraoperative Radiation Therapy (IORT) is an advanced cancer treatment approach where a high dose of radiation is delivered directly to the tumor site during surgery. Once the surgeon removes the tumor, radiation is applied immediately to the exposed area before the incision is closed. This direct delivery allows doctors to target remaining cancer cells with high precision while protecting nearby healthy tissues and organs. Specialized equipment such as mobile linear accelerators, low-energy X-ray systems, or brachytherapy sources are used inside the operating room to perform IORT safely and efficiently.
• IORT is important because it improves treatment accuracy and patient convenience. Traditional radiation therapy usually requires multiple sessions over several weeks. In contrast, IORT can reduce or even eliminate the need for additional post-surgery radiation in selected patients. It lowers the risk of cancer recurrence, minimizes radiation exposure to healthy tissues, shortens hospital visits, and improves overall quality of life. These benefits are especially valuable in breast cancer, colorectal cancer, and other solid tumors where precise local control is critical.
• Looking ahead, the future outlook for the IORT market is promising. Rising global cancer cases, increasing preference for minimally invasive and precision treatments, and expanding oncology infrastructure are driving adoption. Emerging economies are also investing in advanced cancer care, creating new growth opportunities.
• Technological advancements are further strengthening IORT’s role in modern oncology. Portable and compact radiation systems, real-time treatment planning software, image-guided delivery, and integration with robotic surgery are improving accuracy and workflow efficiency. Research into advanced techniques such as FLASH radiotherapy and better applicator designs is also underway. Together, these innovations position IORT as a key component of next-generation, patient-focused cancer treatment.