Protein Engineering Market Synopsis

Protein Engineering Market Size Was Valued at USD 2.7 Billion in 2023, and is Projected to Reach USD 10.5 Billion by 2032, Growing at a CAGR of 16.3% From 2024-2032.

Protein Engineering Market can also be described as that subsegment of the biotechnology industry that deals with engineering and designing of proteins for the sake of use in different contexts of industry, healthcare, and research. So when modest modifications are made to the molecular structure of proteins, researchers are able, for instance, to produce more robust proteins, more effective proteins, or proteins that perform well in particular ways. This market is pulled forward by the rising need for new proteins for pharma, food, agri & industrial enzymes for medicine, food, & for making a sustainable environment & several new industrial applications.

• The Protein Engineering Market has been a rapidly growing market over the recent past, their global sales being influenced by the increasing demand for enhanced proteins in the areas of therapeutics and industry. Advanced diseases like cancer, diabetes and autoimmune diseases have encouraged the development of efficient Biopharmaceuticals and a vast majority of these therapeutic products are protein molecules. By targeting certain diseases proteins have become the new basis of drug development hence the increase in the number of protein drugs. Further, protein engineering also finds its importance in the industrial concern as it is designed enzymes for different manufacturing processes that work better than their existing counterparts with economical and ecofriendly impacts in manufacturing byproducts, biofuel, and food manufacturing.
• This market is further driven by growth of computational biology, genetic engineering, and artificial intelligence that has enhanced the rate at which the discovery and design for protein engineering. Thus, using new technologies, such as directed evolution and the use of methods based on the CRISPR system, researchers can generate new protein variants at a higher speed and with greater accuracy. Therefore, industries such as healthcare, agriculture among others are shifting their gears in ordering for protein engineering technologies in order to meet new demands hence leading to the creation of job spaces at various regions. They envisage the market to grow further as development research takes place and given policies change to allow for new innovation.

Protein Engineering Market Trend Analysis

Advancements in Artificial Intelligence for Protein Design

• Another trend of the Protein Engineering Market is the fact that AI and Machine Learning (ML) technologies are increasingly used in the creation of new proteins. Conventional techniques used in protein engineering including directed evolution and rational design have always been tiresome and cumbersome. However, by the use of advanced technologies such as Artificial intelligence platforms the process is now progressing in a better way and much faster as AI platforms are now predicting the structures and functions of the proteins.
• Artificial intelligence, in particular machine learning, is in use in modeling large sets of data regarding protein interactions in order to design proteins exhibiting desired properties. Application of AI in engineering proteins not only enhance process robustness, but also enhances the prospects of creating proteins with entirely novel functionalities. This trend is very important especially within drug discovery field as the AI tools are being used to develop protein therapeutic that would address complexity of the diseases hence leading to development of personalized medicine.

Growth in Biopharmaceuticals and Therapeutics

• An interesting market is the Protein Engineering Market which is also expected to show steady growth mostly in the biopharmaceutical and therapeutic proteins production. The usage market of biologics such as monoclonal antibodies, vaccines and therapeutic enzymes has been increasing because they work effectively for many chronic and life-threatening diseases. The recourse to protein engineering facilitates the optimisation of these biologics in terms of efficacy, specificity and safety thus qualify them for diversified therapeutic applications.
• The increasing uptake of the so-called targeted therapies, which aim at the activation or inhibition of some biochemical pathways in the body depending on an individual’s genetics, is another consideration that fuels this market. CKD-focused protein-based therapies, including Immunocellular Therapy like CAR-T cell therapy and gene editing employing proteins are on the rise since they address hitherto, untreatable diseases. Since protein based drugs are on the increase today, the market is expected to expand greatly in the future as many pharmaceutical manufacturing companies carry out research and development activities.

Protein Engineering Market Segment Analysis:

Protein Engineering Market Segmented on the basis of Product, Technology, Protein Type and End Use.

By Product, instruments segment is expected to dominate the market during the forecast period

• Regarding the product type system in year 2023, instruments segment held the largest market share with 52.43% in term of total protein engineering market’s product revenue. This segment leadership is mainly in response to the increasing demand for better instruments and systems in protein design, alteration, and characterization. Popular systems like mass spectrometers, chromatography systems, and automated protein synthesizers are critical for accurate protein characterization and development especially in drug discovery and biopharmaceutical production.
• While there is already a significant and growing uptake of protein engineering, this trend is expected to usher in even more advanced levels of precision in protein engineering especially in the therapeutic applications and this will be driven by the instruments segment which therefore will register the highest CAGR into the forcast period. Technological progression in automation of processes and AI will continue to improve instruments used in protein engineering hence spearheading the domination of the instruments segment in this developing market.

By Technology, rational protein design segment expected to held the largest share

• Based on the type of business, it was estimated that in the year 2023 rational protein design will have the largest proportion of Protein Engineering Market share and constitute approximately one-third of the total market share by collecting 31.2% of the total net revenue. This technology involves the intentional engineering of protein structures in view of changing their functional characteristics and patterns of interaction with other proteins. By manipulating the structure and physicochemical properties of the proteins, and employing computational techniques, it is possible to pre-design the consequences of specific alterations to the required function, thereby enabling the synthesis of very effective proteins.
• The steady rise in demand for accurate development of therapeutic proteins and more so in Biopharmaceuticals has resulted to the use of rational protein design. This approach is preferred for it is claimed to be able to generate more consistent results than other techniques that can be used such as directed evolution. As industries continue to demand more precise and reliable proteins for numerous functional uses, thus, it is anticipated that the rational protein design shall still remain as the market leader with reasonable contribution to the market growth.

Protein Engineering Market Regional Insights:

North America is Expected to Dominate the Market Over the Forecast period

• When the expansion of the Protein Engineering Market is assessed for the forecast period 2023, it is found that North America region is the largest PK market. The region has already gained a leadership position due to the development of the industry and the availability of healthcare infrastructure in the biopharmaceutical business, investment in research and development. The United States in particular, is central to this market home to a large number of players within the pharmaceutical and research institute zones that are pioneering the protein engineering market. North American 2023 account for about 45 % of the overall global market because of the key players, government encouragement for carrying out research on biotechnology, and rising requirement for biologic goods. Also, utilizing advanced tools such as AI and machine learning in proteins design also puts North America on a leading stand. The North American market has also been slowed down by the growth of other protein engineering markets such as Europe and Asia-Pacific region; however, owing to a strong established R &D infrastructure and favorable regulations, North America has been able to sustain itself as one of the premier markets for protein engineering.

Active Key Players in the Protein Engineering Market

• Agilent Technologies (United States)
• Amgen Inc. (United States)
• Bio-Rad Laboratories (United States)
• Bruker Corporation (United States)
• Codexis, Inc. (United States)
• Danaher Corporation (United States)
• Genscript Biotech Corporation (China)
• Lonza Group (Switzerland)
• Merck KGaA (Germany)
• Novozymes (Denmark)
• PerkinElmer, Inc. (United States)
• Pfizer Inc. (United States)
• Sartorius AG (Germany)
• Thermo Fisher Scientific (United States)
• Waters Corporation (United States)
• Other key Players

Chapter 1: Introduction
 1.1 Scope and Coverage

Chapter 2:Executive Summary

Chapter 3: Market Landscape
 3.1 Market Dynamics
  3.1.1 Drivers
  3.1.2 Restraints
  3.1.3 Opportunities
  3.1.4 Challenges
 3.2 Market Trend Analysis
 3.3 PESTLE Analysis
 3.4 Porter's Five Forces Analysis
 3.5 Industry Value Chain Analysis
 3.6 Ecosystem
 3.7 Regulatory Landscape
 3.8 Price Trend Analysis
 3.9 Patent Analysis
 3.10 Technology Evolution
 3.11 Investment Pockets
 3.12 Import-Export Analysis

Chapter 4: Protein Engineering Market by Product
 4.1 Protein Engineering Market Snapshot and Growth Engine
 4.2 Protein Engineering Market Overview
 4.3 Instruments
  4.3.1 Introduction and Market Overview
  4.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.3.3 Key Market Trends, Growth Factors and Opportunities
  4.3.4 Instruments: Geographic Segmentation Analysis
 4.4 Reagents
  4.4.1 Introduction and Market Overview
  4.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.4.3 Key Market Trends, Growth Factors and Opportunities
  4.4.4 Reagents: Geographic Segmentation Analysis
 4.5 Software
  4.5.1 Introduction and Market Overview
  4.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.5.3 Key Market Trends, Growth Factors and Opportunities
  4.5.4 Software: Geographic Segmentation Analysis
 4.6 Services
  4.6.1 Introduction and Market Overview
  4.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.6.3 Key Market Trends, Growth Factors and Opportunities
  4.6.4 Services: Geographic Segmentation Analysis

Chapter 5: Protein Engineering Market by Technology
 5.1 Protein Engineering Market Snapshot and Growth Engine
 5.2 Protein Engineering Market Overview
 5.3 Rational Protein Design
  5.3.1 Introduction and Market Overview
  5.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.3.3 Key Market Trends, Growth Factors and Opportunities
  5.3.4 Rational Protein Design: Geographic Segmentation Analysis
 5.4 Directed Evolution
  5.4.1 Introduction and Market Overview
  5.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.4.3 Key Market Trends, Growth Factors and Opportunities
  5.4.4 Directed Evolution: Geographic Segmentation Analysis
 5.5 Hybrid Approach
  5.5.1 Introduction and Market Overview
  5.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.5.3 Key Market Trends, Growth Factors and Opportunities
  5.5.4 Hybrid Approach: Geographic Segmentation Analysis
 5.6 De Novo Protein Design
  5.6.1 Introduction and Market Overview
  5.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.6.3 Key Market Trends, Growth Factors and Opportunities
  5.6.4 De Novo Protein Design: Geographic Segmentation Analysis

Chapter 6: Protein Engineering Market by Protein Type
 6.1 Protein Engineering Market Snapshot and Growth Engine
 6.2 Protein Engineering Market Overview
 6.3 Insulin
  6.3.1 Introduction and Market Overview
  6.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.3.3 Key Market Trends, Growth Factors and Opportunities
  6.3.4 Insulin: Geographic Segmentation Analysis
 6.4 Monoclonal Antibodies
  6.4.1 Introduction and Market Overview
  6.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.4.3 Key Market Trends, Growth Factors and Opportunities
  6.4.4 Monoclonal Antibodies: Geographic Segmentation Analysis
 6.5 Vaccines
  6.5.1 Introduction and Market Overview
  6.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.5.3 Key Market Trends, Growth Factors and Opportunities
  6.5.4 Vaccines: Geographic Segmentation Analysis
 6.6 Growth Factors
  6.6.1 Introduction and Market Overview
  6.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.6.3 Key Market Trends, Growth Factors and Opportunities
  6.6.4 Growth Factors: Geographic Segmentation Analysis
 6.7 Colony Stimulating Factors
  6.7.1 Introduction and Market Overview
  6.7.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.7.3 Key Market Trends, Growth Factors and Opportunities
  6.7.4 Colony Stimulating Factors: Geographic Segmentation Analysis
 6.8 Coagulation Factors
  6.8.1 Introduction and Market Overview
  6.8.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.8.3 Key Market Trends, Growth Factors and Opportunities
  6.8.4 Coagulation Factors: Geographic Segmentation Analysis
 6.9 Interferon
  6.9.1 Introduction and Market Overview
  6.9.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.9.3 Key Market Trends, Growth Factors and Opportunities
  6.9.4 Interferon: Geographic Segmentation Analysis

Chapter 7: Protein Engineering Market by End Use
 7.1 Protein Engineering Market Snapshot and Growth Engine
 7.2 Protein Engineering Market Overview
 7.3 Academic Research Institutes
  7.3.1 Introduction and Market Overview
  7.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  7.3.3 Key Market Trends, Growth Factors and Opportunities
  7.3.4 Academic Research Institutes: Geographic Segmentation Analysis
 7.4 Contract Research Organizations
  7.4.1 Introduction and Market Overview
  7.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  7.4.3 Key Market Trends, Growth Factors and Opportunities
  7.4.4 Contract Research Organizations: Geographic Segmentation Analysis
 7.5 Pharmaceutical & Biotechnology Companies
  7.5.1 Introduction and Market Overview
  7.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  7.5.3 Key Market Trends, Growth Factors and Opportunities
  7.5.4 Pharmaceutical & Biotechnology Companies: Geographic Segmentation Analysis

Chapter 8: Company Profiles and Competitive Analysis
 8.1 Competitive Landscape
  8.1.1 Competitive Benchmarking
  8.1.2 Protein Engineering Market Share by Manufacturer (2023)
  8.1.3 Industry BCG Matrix
  8.1.4 Heat Map Analysis
  8.1.5 Mergers and Acquisitions
  
 8.2 AGILENT TECHNOLOGIES (UNITED STATES)
  8.2.1 Company Overview
  8.2.2 Key Executives
  8.2.3 Company Snapshot
  8.2.4 Role of the Company in the Market
  8.2.5 Sustainability and Social Responsibility
  8.2.6 Operating Business Segments
  8.2.7 Product Portfolio
  8.2.8 Business Performance
  8.2.9 Key Strategic Moves and Recent Developments
  8.2.10 SWOT Analysis
 8.3 AMGEN INC (UNITED STATES)
 8.4 BIO-RAD LABORATORIES (UNITED STATES)
 8.5 BRUKER CORPORATION (UNITED STATES)
 8.6 CODEXIS
 8.7 INC (UNITED STATES)
 8.8 OTHER ACTIVE PLAYERS

Chapter 9: Global Protein Engineering Market By Region
 9.1 Overview
 9.2. North America Protein Engineering Market
  9.2.1 Key Market Trends, Growth Factors and Opportunities
  9.2.2 Top Key Companies
  9.2.3 Historic and Forecasted Market Size by Segments
  9.2.4 Historic and Forecasted Market Size By Product
  9.2.4.1 Instruments
  9.2.4.2 Reagents
  9.2.4.3 Software
  9.2.4.4 Services
  9.2.5 Historic and Forecasted Market Size By Technology
  9.2.5.1 Rational Protein Design
  9.2.5.2 Directed Evolution
  9.2.5.3 Hybrid Approach
  9.2.5.4 De Novo Protein Design
  9.2.6 Historic and Forecasted Market Size By Protein Type
  9.2.6.1 Insulin
  9.2.6.2 Monoclonal Antibodies
  9.2.6.3 Vaccines
  9.2.6.4 Growth Factors
  9.2.6.5 Colony Stimulating Factors
  9.2.6.6 Coagulation Factors
  9.2.6.7 Interferon
  9.2.7 Historic and Forecasted Market Size By End Use
  9.2.7.1 Academic Research Institutes
  9.2.7.2 Contract Research Organizations
  9.2.7.3 Pharmaceutical & Biotechnology Companies
  9.2.8 Historic and Forecast Market Size by Country
  9.2.8.1 US
  9.2.8.2 Canada
  9.2.8.3 Mexico
 9.3. Eastern Europe Protein Engineering Market
  9.3.1 Key Market Trends, Growth Factors and Opportunities
  9.3.2 Top Key Companies
  9.3.3 Historic and Forecasted Market Size by Segments
  9.3.4 Historic and Forecasted Market Size By Product
  9.3.4.1 Instruments
  9.3.4.2 Reagents
  9.3.4.3 Software
  9.3.4.4 Services
  9.3.5 Historic and Forecasted Market Size By Technology
  9.3.5.1 Rational Protein Design
  9.3.5.2 Directed Evolution
  9.3.5.3 Hybrid Approach
  9.3.5.4 De Novo Protein Design
  9.3.6 Historic and Forecasted Market Size By Protein Type
  9.3.6.1 Insulin
  9.3.6.2 Monoclonal Antibodies
  9.3.6.3 Vaccines
  9.3.6.4 Growth Factors
  9.3.6.5 Colony Stimulating Factors
  9.3.6.6 Coagulation Factors
  9.3.6.7 Interferon
  9.3.7 Historic and Forecasted Market Size By End Use
  9.3.7.1 Academic Research Institutes
  9.3.7.2 Contract Research Organizations
  9.3.7.3 Pharmaceutical & Biotechnology Companies
  9.3.8 Historic and Forecast Market Size by Country
  9.3.8.1 Bulgaria
  9.3.8.2 The Czech Republic
  9.3.8.3 Hungary
  9.3.8.4 Poland
  9.3.8.5 Romania
  9.3.8.6 Rest of Eastern Europe
 9.4. Western Europe Protein Engineering Market
  9.4.1 Key Market Trends, Growth Factors and Opportunities
  9.4.2 Top Key Companies
  9.4.3 Historic and Forecasted Market Size by Segments
  9.4.4 Historic and Forecasted Market Size By Product
  9.4.4.1 Instruments
  9.4.4.2 Reagents
  9.4.4.3 Software
  9.4.4.4 Services
  9.4.5 Historic and Forecasted Market Size By Technology
  9.4.5.1 Rational Protein Design
  9.4.5.2 Directed Evolution
  9.4.5.3 Hybrid Approach
  9.4.5.4 De Novo Protein Design
  9.4.6 Historic and Forecasted Market Size By Protein Type
  9.4.6.1 Insulin
  9.4.6.2 Monoclonal Antibodies
  9.4.6.3 Vaccines
  9.4.6.4 Growth Factors
  9.4.6.5 Colony Stimulating Factors
  9.4.6.6 Coagulation Factors
  9.4.6.7 Interferon
  9.4.7 Historic and Forecasted Market Size By End Use
  9.4.7.1 Academic Research Institutes
  9.4.7.2 Contract Research Organizations
  9.4.7.3 Pharmaceutical & Biotechnology Companies
  9.4.8 Historic and Forecast Market Size by Country
  9.4.8.1 Germany
  9.4.8.2 UK
  9.4.8.3 France
  9.4.8.4 Netherlands
  9.4.8.5 Italy
  9.4.8.6 Russia
  9.4.8.7 Spain
  9.4.8.8 Rest of Western Europe
 9.5. Asia Pacific Protein Engineering Market
  9.5.1 Key Market Trends, Growth Factors and Opportunities
  9.5.2 Top Key Companies
  9.5.3 Historic and Forecasted Market Size by Segments
  9.5.4 Historic and Forecasted Market Size By Product
  9.5.4.1 Instruments
  9.5.4.2 Reagents
  9.5.4.3 Software
  9.5.4.4 Services
  9.5.5 Historic and Forecasted Market Size By Technology
  9.5.5.1 Rational Protein Design
  9.5.5.2 Directed Evolution
  9.5.5.3 Hybrid Approach
  9.5.5.4 De Novo Protein Design
  9.5.6 Historic and Forecasted Market Size By Protein Type
  9.5.6.1 Insulin
  9.5.6.2 Monoclonal Antibodies
  9.5.6.3 Vaccines
  9.5.6.4 Growth Factors
  9.5.6.5 Colony Stimulating Factors
  9.5.6.6 Coagulation Factors
  9.5.6.7 Interferon
  9.5.7 Historic and Forecasted Market Size By End Use
  9.5.7.1 Academic Research Institutes
  9.5.7.2 Contract Research Organizations
  9.5.7.3 Pharmaceutical & Biotechnology Companies
  9.5.8 Historic and Forecast Market Size by Country
  9.5.8.1 China
  9.5.8.2 India
  9.5.8.3 Japan
  9.5.8.4 South Korea
  9.5.8.5 Malaysia
  9.5.8.6 Thailand
  9.5.8.7 Vietnam
  9.5.8.8 The Philippines
  9.5.8.9 Australia
  9.5.8.10 New Zealand
  9.5.8.11 Rest of APAC
 9.6. Middle East & Africa Protein Engineering Market
  9.6.1 Key Market Trends, Growth Factors and Opportunities
  9.6.2 Top Key Companies
  9.6.3 Historic and Forecasted Market Size by Segments
  9.6.4 Historic and Forecasted Market Size By Product
  9.6.4.1 Instruments
  9.6.4.2 Reagents
  9.6.4.3 Software
  9.6.4.4 Services
  9.6.5 Historic and Forecasted Market Size By Technology
  9.6.5.1 Rational Protein Design
  9.6.5.2 Directed Evolution
  9.6.5.3 Hybrid Approach
  9.6.5.4 De Novo Protein Design
  9.6.6 Historic and Forecasted Market Size By Protein Type
  9.6.6.1 Insulin
  9.6.6.2 Monoclonal Antibodies
  9.6.6.3 Vaccines
  9.6.6.4 Growth Factors
  9.6.6.5 Colony Stimulating Factors
  9.6.6.6 Coagulation Factors
  9.6.6.7 Interferon
  9.6.7 Historic and Forecasted Market Size By End Use
  9.6.7.1 Academic Research Institutes
  9.6.7.2 Contract Research Organizations
  9.6.7.3 Pharmaceutical & Biotechnology Companies
  9.6.8 Historic and Forecast Market Size by Country
  9.6.8.1 Turkey
  9.6.8.2 Bahrain
  9.6.8.3 Kuwait
  9.6.8.4 Saudi Arabia
  9.6.8.5 Qatar
  9.6.8.6 UAE
  9.6.8.7 Israel
  9.6.8.8 South Africa
 9.7. South America Protein Engineering Market
  9.7.1 Key Market Trends, Growth Factors and Opportunities
  9.7.2 Top Key Companies
  9.7.3 Historic and Forecasted Market Size by Segments
  9.7.4 Historic and Forecasted Market Size By Product
  9.7.4.1 Instruments
  9.7.4.2 Reagents
  9.7.4.3 Software
  9.7.4.4 Services
  9.7.5 Historic and Forecasted Market Size By Technology
  9.7.5.1 Rational Protein Design
  9.7.5.2 Directed Evolution
  9.7.5.3 Hybrid Approach
  9.7.5.4 De Novo Protein Design
  9.7.6 Historic and Forecasted Market Size By Protein Type
  9.7.6.1 Insulin
  9.7.6.2 Monoclonal Antibodies
  9.7.6.3 Vaccines
  9.7.6.4 Growth Factors
  9.7.6.5 Colony Stimulating Factors
  9.7.6.6 Coagulation Factors
  9.7.6.7 Interferon
  9.7.7 Historic and Forecasted Market Size By End Use
  9.7.7.1 Academic Research Institutes
  9.7.7.2 Contract Research Organizations
  9.7.7.3 Pharmaceutical & Biotechnology Companies
  9.7.8 Historic and Forecast Market Size by Country
  9.7.8.1 Brazil
  9.7.8.2 Argentina
  9.7.8.3 Rest of SA

Chapter 10 Analyst Viewpoint and Conclusion
10.1 Recommendations and Concluding Analysis
10.2 Potential Market Strategies

Chapter 11 Research Methodology
11.1 Research Process
11.2 Primary Research
11.3 Secondary Research