Personalized Cell Therapy Market Synopsis

Personalized Cell Therapy Market Size Was Valued at USD  15.1 Billion in 2023, and is Projected to Reach USD  114.63 Billion by 2032, Growing at a CAGR of 25% From 2024-2032.

Personalized cell therapy is the use of cells to address different diseases with treatment customized for the patients. These therapies use stem cells, immune cells or genetically amended cells with cancer, cardiovascular diseases and neurological diseases respectively presenting a personalized/precision medicine approach.

• The global market for personalized cell therapy is growing at a very fast pace due to recent developments in biological technology and increased need to treat patients as individuals. Cell-based therapies: They are particularly significant in today’s developing and evolving system of global healthcare because as diseases and ailments become more and more complex there is a demand for ever more specific treatments. Some of the major uses of stem cell therapies are in cancer, heart diseases, main nervous system disorders and diabetes where standard medicine fails to deliver. Cell therapy entails use of patient cells or other donor cells that serve certain functions, especially in restoring tissues at the body, regulating immunity or killing cancerous cells. The trends towards regenerative medicine and enhanced cellular knowledge have advanced the discovery and monetization of these therapies, with a myriad of trials under way around the globe.
• Overall, the level of investment that has been committed to personal cell therapy is considerably high and more so there is synergy between the pharmaceutical companies, biotechnology firms and academic institutions in the development of cell therapy. Legal requirements, including approvals from US-FDA and EMA, have also supported the market, which laid down the means for new-generation treatments to get to patients. However, the cost of developing and manufacturing is extremely high which stands as a big barrier in making these treatments available. Much like before, governments and private entities are investing in manufacturing infrastructure, and the costs associated with scale are being driving down. Still, the individualised cell therapy market remains promising and the constant research outcomes are expected to provide solutions that will completely transform the future of medicine.

Personalized Cell Therapy Market Trend Analysis

Advancements in Gene-Editing Techniques

• Incorporation of gene editing technologies more so CRISPR-Cas9 has been a key trend observed to be defining the personalized cell therapy market. Gene-editing makes it possible to alter DNA in cells selectively and efficiently giving it the potential of the provision of superior treatments. The above approach is also useful to patients with genetic diseases as well as cancer, which is known to be caused by certain gene mutations. Gene editing improves the effectiveness of individual treatments because the tools adjust cells to remove these mutations.
• Another advance is the partnership between gene editing tools and the clinical immune cell therapies like CAR T Cells. Through gene-editing, the researchers have been able to develop superior treatment for the immune cells that can target the cancer cells much more effectively. It was anticipated that as these technologies advance further, they would create possibilities for individualized treatment in a number of other diseases, thus advancing the spectrum beyond what contemporary technology can offer..

Expanding Use in Neurological Disorders

• Neurological disorders are arguably the largest opportunity area for personalized cell therapy because the current therapies are generally ineffective in most neurological disease categories. Parkinsonism; Alzheimers; spinal cord injury are some of the diseases showing signs of reasonable promise due to their characteristics of cell degeneration particularly of a certain type as is the case with neurons. Customized cell solutions can grow these lost cells back and enhance neurological capabilities for patients who previously have no treatment available.
• There are several on-going clinical trials aimed at determining the ability of stem cell therapy to replace neurons and other important cells of the nervous system. As more clinical research is to be carried out and positive outcomes are to be reported, personalized cell therapy in neurology will likely evolve offering a novel approach to care where there is a lack of effective treatments. The increasing life span and the growing prevalence of neurological disorders make this area one of the most exciting and attractive prospects for the development of individualized medicine.

Personalized Cell Therapy Market Segment Analysis:

• Personalized Cell Therapy Market Segmented based on  Cell Type,  Distribution Channel,Application, and End User.

By   Cell Type,  Embryonic Stem Cells segment is expected to dominate the market during the forecast period

• Targeted cell therapy can be classified based on its cellular origins as embryonic stem cells, differentiated adult stem cells, initiator cells or other types. Given that ES cells are generated from the blastocysts, they possess the differentiation capability of producing or generating a particular cell type and hence carry the possibilities of regenerative medicine. But their application remains limited, specifically because of the ethical issues. On the other hand adult stem cells for example in the bone marrow present relatively few problems of ethic but have a comparatively lower capability to differentiate. More are the iPSCs made from the adult stem cells through the process of reprogramming of somatic cells to the pluripotent embryonic status, they are getting popular due to their ethical advantage without undermining their pluripotency.
• There are pros and cons associated with each cell type: iPSCs are most commonly applied to research to develop patient-derived model of diseases, and drug screening, while adult stem cells find their applications in immune related disorders, like graft-versus-host disease. The decision in terms of which cell type to use is dependent on the disease to be targeted and the objectives of the treatment making this segment a very active and constantly changing segment.

By Application , Neurological Disorders  segment held the largest share in 2023

• Looking into cell therapy solutions, they are focused on the individual patient cellular approaches used in the treatment of cardiovascular diseases, neurological disorders, diabetes, oncology, and other. In cardiovascular diseases, stem cells are being tested in an attempt to rebuild broken arteries and to enhance the heart’s ability to pump blood should there have been a heart attack. Neurological applications take a shot at growing new neurons, which are missing in diseases such as Parkinson’s disease and multiple sclerosis in which standard medical remedies prove futile.
• In zar oncology, the null cell therapy is made to attack only the cancer cells with high selectivity to help the patients with resistant or relapse cancers. Diabetes is another exciting field relevant to the subject where scientists are attempting to gift the body with stem cells that may help regenerate the insulin producing beta cells of the pancreas to cure type 1 diabetes. Every specialty presents its own set of problems and possibilities, but the concept of individualized therapies continuing to yield major boost to the treatment process remains quite viable in all claims.

Personalized Cell Therapy Market Regional Insights:

North America is Expected to Dominate the Market Over the Forecast period

• North America, especially the United States holds a lion share of the personalized cell therapy market. The region stands as one of the most explored in the biotechnology field, and boasting of the best healthcare systems, and beefed up investment in clinical trials, makes the development, and commercialization of personalized medicine a key area. In the last few years, there are more FDA approved personalized cell therapies in the U.S., especially in Oncology and regenerative medicine, consolidating its leadership.
• Furthermore, arising information dependency has been supported by well established initial major players of pharmaceutical and biotechnology industries, as well as competent patronship from academic sectors. Canada is also one of the actors increasing the region’s dominance through expanding research activities and collaborations. Technological progress, strict compliance with the norms and standards of the regulation, and higher patients’ demand for individualized treatment are still staying as the major factors of the industry’s growth in North America.

Active Key Players in the Personalized Cell Therapy Market

• Novartis (Switzerland)
• Gilead Sciences (USA)
• Pfizer (USA)
• Roche (Switzerland)
• Bristol-Myers Squibb (USA)
• Bluebird Bio (USA)
• Cellectis (France)
• CARsgen Therapeutics (China)
• Kite Pharma (USA)
• Atara Biotherapeutics (USA)
• Celgene Corporation (USA)
• Vericel Corporation (USA)
• Sangamo Therapeutics (USA)
• Mesoblast Ltd (Australia)
• Adaptimmune Therapeutics (UK)
• Others Key Player

Key Industry Developments in the Personalized Cell Therapy Market

• On March 14, 2024, Bristol Myers Squibb, Pharmaceutical company has announced that the U.S. Food and Drug Administration (FDA) granted accelerated approval for Breyanzi (lisocabtagene maraleucel; liso-cel), a CD19-directed CAR T cell therapy. This approval is for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have received at least two prior lines of therapy, including specific inhibitors.
• In October 2023, Aurion Biotech, a clinical stage biotech company initiated a phase 1/2 clinical trial for AURN001, a novel cell therapy targeting corneal edema caused by corneal endothelial dysfunction. This therapy combines Y-27632, a Rho kinase inhibitor, with allogenic human corneal endothelial cells (neltependocel).
• In June 2023, Vertex Pharmaceuticals, BioPharmaceutical company Incorporated and Lonza announced a strategic collaboration to enhance manufacturing capabilities for Vertex's differentiated islet cell therapies aimed at producing insulin for individuals with type 1 diabetes. This partnership focuses on advancing the VX-264 and VX-880 programs, both currently in clinical trials.
• In May 2023, Janssen Biotech, Inc., a subsidiary of Johnson & Johnson, entered into a global collaboration and licensing agreement with Cellular Biomedicine Group Inc. (CBMG) to jointly develop, manufacture, and commercialize advanced CAR T-cell therapies for the treatment of B-cell malignancies.

Chapter 1: Introduction
 1.1 Scope and Coverage

Chapter 2:Executive Summary

Chapter 3: Market Landscape
 3.1 Market Dynamics
  3.1.1 Drivers
  3.1.2 Restraints
  3.1.3 Opportunities
  3.1.4 Challenges
 3.2 Market Trend Analysis
 3.3 PESTLE Analysis
 3.4 Porter's Five Forces Analysis
 3.5 Industry Value Chain Analysis
 3.6 Ecosystem
 3.7 Regulatory Landscape
 3.8 Price Trend Analysis
 3.9 Patent Analysis
 3.10 Technology Evolution
 3.11 Investment Pockets
 3.12 Import-Export Analysis

Chapter 4: Personalized Cell Therapy Market by Cell Type
 4.1 Personalized Cell Therapy Market Snapshot and Growth Engine
 4.2 Personalized Cell Therapy Market Overview
 4.3 Embryonic Stem Cells
  4.3.1 Introduction and Market Overview
  4.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.3.3 Key Market Trends, Growth Factors and Opportunities
  4.3.4 Embryonic Stem Cells: Geographic Segmentation Analysis
 4.4 Adult Stem Cell
  4.4.1 Introduction and Market Overview
  4.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.4.3 Key Market Trends, Growth Factors and Opportunities
  4.4.4 Adult Stem Cell: Geographic Segmentation Analysis
 4.5 Induced Pluripotent Cells
  4.5.1 Introduction and Market Overview
  4.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.5.3 Key Market Trends, Growth Factors and Opportunities
  4.5.4 Induced Pluripotent Cells: Geographic Segmentation Analysis
 4.6 Others
  4.6.1 Introduction and Market Overview
  4.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.6.3 Key Market Trends, Growth Factors and Opportunities
  4.6.4 Others: Geographic Segmentation Analysis

Chapter 5: Personalized Cell Therapy Market by Application
 5.1 Personalized Cell Therapy Market Snapshot and Growth Engine
 5.2 Personalized Cell Therapy Market Overview
 5.3 Cardiovascular Diseases
  5.3.1 Introduction and Market Overview
  5.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.3.3 Key Market Trends, Growth Factors and Opportunities
  5.3.4 Cardiovascular Diseases: Geographic Segmentation Analysis
 5.4 Neurological Disorders
  5.4.1 Introduction and Market Overview
  5.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.4.3 Key Market Trends, Growth Factors and Opportunities
  5.4.4 Neurological Disorders: Geographic Segmentation Analysis
 5.5 Diabetes
  5.5.1 Introduction and Market Overview
  5.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.5.3 Key Market Trends, Growth Factors and Opportunities
  5.5.4 Diabetes: Geographic Segmentation Analysis
 5.6 Oncology
  5.6.1 Introduction and Market Overview
  5.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.6.3 Key Market Trends, Growth Factors and Opportunities
  5.6.4 Oncology: Geographic Segmentation Analysis
 5.7 Others)
  5.7.1 Introduction and Market Overview
  5.7.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.7.3 Key Market Trends, Growth Factors and Opportunities
  5.7.4 Others): Geographic Segmentation Analysis
 5.8 By End User(Hospitals
  5.8.1 Introduction and Market Overview
  5.8.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.8.3 Key Market Trends, Growth Factors and Opportunities
  5.8.4 By End User(Hospitals: Geographic Segmentation Analysis
 5.9 Homecare
  5.9.1 Introduction and Market Overview
  5.9.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.9.3 Key Market Trends, Growth Factors and Opportunities
  5.9.4 Homecare: Geographic Segmentation Analysis
 5.10 Specialty Clinics
  5.10.1 Introduction and Market Overview
  5.10.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.10.3 Key Market Trends, Growth Factors and Opportunities
  5.10.4 Specialty Clinics: Geographic Segmentation Analysis
 5.11 Others)
  5.11.1 Introduction and Market Overview
  5.11.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.11.3 Key Market Trends, Growth Factors and Opportunities
  5.11.4 Others): Geographic Segmentation Analysis
 5.12 By Distribution Channel(Hospital Pharmacy
  5.12.1 Introduction and Market Overview
  5.12.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.12.3 Key Market Trends, Growth Factors and Opportunities
  5.12.4 By Distribution Channel(Hospital Pharmacy: Geographic Segmentation Analysis
 5.13 Online Pharmacy
  5.13.1 Introduction and Market Overview
  5.13.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.13.3 Key Market Trends, Growth Factors and Opportunities
  5.13.4 Online Pharmacy: Geographic Segmentation Analysis
 5.14 Retail Pharmacy
  5.14.1 Introduction and Market Overview
  5.14.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.14.3 Key Market Trends, Growth Factors and Opportunities
  5.14.4 Retail Pharmacy: Geographic Segmentation Analysis

Chapter 6: Company Profiles and Competitive Analysis
 6.1 Competitive Landscape
  6.1.1 Competitive Benchmarking
  6.1.2 Personalized Cell Therapy Market Share by Manufacturer (2023)
  6.1.3 Industry BCG Matrix
  6.1.4 Heat Map Analysis
  6.1.5 Mergers and Acquisitions
  
 6.2 NOVARTIS
  6.2.1 Company Overview
  6.2.2 Key Executives
  6.2.3 Company Snapshot
  6.2.4 Role of the Company in the Market
  6.2.5 Sustainability and Social Responsibility
  6.2.6 Operating Business Segments
  6.2.7 Product Portfolio
  6.2.8 Business Performance
  6.2.9 Key Strategic Moves and Recent Developments
  6.2.10 SWOT Analysis
 6.3 GILEAD SCIENCES
 6.4 PFIZER
 6.5 ROCHE
 6.6 BRISTOL-MYERS SQUIBB
 6.7 BLUEBIRD BIO
 6.8 CELLECTIS
 6.9 CARSGEN THERAPEUTICS
 6.10 KITE PHARMA
 6.11 ATARA BIOTHERAPEUTICS
 6.12 CELGENE CORPORATION
 6.13 VERICEL CORPORATION
 6.14 SANGAMO THERAPEUTICS
 6.15 MESOBLAST LTD
 6.16 ADAPTIMMUNE THERAPEUTICS
 6.17 OTHERS KEY PLAYER.

Chapter 7: Global Personalized Cell Therapy Market By Region
 7.1 Overview
 7.2. North America Personalized Cell Therapy Market
  7.2.1 Key Market Trends, Growth Factors and Opportunities
  7.2.2 Top Key Companies
  7.2.3 Historic and Forecasted Market Size by Segments
  7.2.4 Historic and Forecasted Market Size By Cell Type
  7.2.4.1 Embryonic Stem Cells
  7.2.4.2 Adult Stem Cell
  7.2.4.3 Induced Pluripotent Cells
  7.2.4.4 Others
  7.2.5 Historic and Forecasted Market Size By Application
  7.2.5.1 Cardiovascular Diseases
  7.2.5.2 Neurological Disorders
  7.2.5.3 Diabetes
  7.2.5.4 Oncology
  7.2.5.5 Others)
  7.2.5.6 By End User(Hospitals
  7.2.5.7 Homecare
  7.2.5.8 Specialty Clinics
  7.2.5.9 Others)
  7.2.5.10 By Distribution Channel(Hospital Pharmacy
  7.2.5.11 Online Pharmacy
  7.2.5.12 Retail Pharmacy
  7.2.6 Historic and Forecast Market Size by Country
  7.2.6.1 US
  7.2.6.2 Canada
  7.2.6.3 Mexico
 7.3. Eastern Europe Personalized Cell Therapy Market
  7.3.1 Key Market Trends, Growth Factors and Opportunities
  7.3.2 Top Key Companies
  7.3.3 Historic and Forecasted Market Size by Segments
  7.3.4 Historic and Forecasted Market Size By Cell Type
  7.3.4.1 Embryonic Stem Cells
  7.3.4.2 Adult Stem Cell
  7.3.4.3 Induced Pluripotent Cells
  7.3.4.4 Others
  7.3.5 Historic and Forecasted Market Size By Application
  7.3.5.1 Cardiovascular Diseases
  7.3.5.2 Neurological Disorders
  7.3.5.3 Diabetes
  7.3.5.4 Oncology
  7.3.5.5 Others)
  7.3.5.6 By End User(Hospitals
  7.3.5.7 Homecare
  7.3.5.8 Specialty Clinics
  7.3.5.9 Others)
  7.3.5.10 By Distribution Channel(Hospital Pharmacy
  7.3.5.11 Online Pharmacy
  7.3.5.12 Retail Pharmacy
  7.3.6 Historic and Forecast Market Size by Country
  7.3.6.1 Bulgaria
  7.3.6.2 The Czech Republic
  7.3.6.3 Hungary
  7.3.6.4 Poland
  7.3.6.5 Romania
  7.3.6.6 Rest of Eastern Europe
 7.4. Western Europe Personalized Cell Therapy Market
  7.4.1 Key Market Trends, Growth Factors and Opportunities
  7.4.2 Top Key Companies
  7.4.3 Historic and Forecasted Market Size by Segments
  7.4.4 Historic and Forecasted Market Size By Cell Type
  7.4.4.1 Embryonic Stem Cells
  7.4.4.2 Adult Stem Cell
  7.4.4.3 Induced Pluripotent Cells
  7.4.4.4 Others
  7.4.5 Historic and Forecasted Market Size By Application
  7.4.5.1 Cardiovascular Diseases
  7.4.5.2 Neurological Disorders
  7.4.5.3 Diabetes
  7.4.5.4 Oncology
  7.4.5.5 Others)
  7.4.5.6 By End User(Hospitals
  7.4.5.7 Homecare
  7.4.5.8 Specialty Clinics
  7.4.5.9 Others)
  7.4.5.10 By Distribution Channel(Hospital Pharmacy
  7.4.5.11 Online Pharmacy
  7.4.5.12 Retail Pharmacy
  7.4.6 Historic and Forecast Market Size by Country
  7.4.6.1 Germany
  7.4.6.2 UK
  7.4.6.3 France
  7.4.6.4 Netherlands
  7.4.6.5 Italy
  7.4.6.6 Russia
  7.4.6.7 Spain
  7.4.6.8 Rest of Western Europe
 7.5. Asia Pacific Personalized Cell Therapy Market
  7.5.1 Key Market Trends, Growth Factors and Opportunities
  7.5.2 Top Key Companies
  7.5.3 Historic and Forecasted Market Size by Segments
  7.5.4 Historic and Forecasted Market Size By Cell Type
  7.5.4.1 Embryonic Stem Cells
  7.5.4.2 Adult Stem Cell
  7.5.4.3 Induced Pluripotent Cells
  7.5.4.4 Others
  7.5.5 Historic and Forecasted Market Size By Application
  7.5.5.1 Cardiovascular Diseases
  7.5.5.2 Neurological Disorders
  7.5.5.3 Diabetes
  7.5.5.4 Oncology
  7.5.5.5 Others)
  7.5.5.6 By End User(Hospitals
  7.5.5.7 Homecare
  7.5.5.8 Specialty Clinics
  7.5.5.9 Others)
  7.5.5.10 By Distribution Channel(Hospital Pharmacy
  7.5.5.11 Online Pharmacy
  7.5.5.12 Retail Pharmacy
  7.5.6 Historic and Forecast Market Size by Country
  7.5.6.1 China
  7.5.6.2 India
  7.5.6.3 Japan
  7.5.6.4 South Korea
  7.5.6.5 Malaysia
  7.5.6.6 Thailand
  7.5.6.7 Vietnam
  7.5.6.8 The Philippines
  7.5.6.9 Australia
  7.5.6.10 New Zealand
  7.5.6.11 Rest of APAC
 7.6. Middle East & Africa Personalized Cell Therapy Market
  7.6.1 Key Market Trends, Growth Factors and Opportunities
  7.6.2 Top Key Companies
  7.6.3 Historic and Forecasted Market Size by Segments
  7.6.4 Historic and Forecasted Market Size By Cell Type
  7.6.4.1 Embryonic Stem Cells
  7.6.4.2 Adult Stem Cell
  7.6.4.3 Induced Pluripotent Cells
  7.6.4.4 Others
  7.6.5 Historic and Forecasted Market Size By Application
  7.6.5.1 Cardiovascular Diseases
  7.6.5.2 Neurological Disorders
  7.6.5.3 Diabetes
  7.6.5.4 Oncology
  7.6.5.5 Others)
  7.6.5.6 By End User(Hospitals
  7.6.5.7 Homecare
  7.6.5.8 Specialty Clinics
  7.6.5.9 Others)
  7.6.5.10 By Distribution Channel(Hospital Pharmacy
  7.6.5.11 Online Pharmacy
  7.6.5.12 Retail Pharmacy
  7.6.6 Historic and Forecast Market Size by Country
  7.6.6.1 Turkey
  7.6.6.2 Bahrain
  7.6.6.3 Kuwait
  7.6.6.4 Saudi Arabia
  7.6.6.5 Qatar
  7.6.6.6 UAE
  7.6.6.7 Israel
  7.6.6.8 South Africa
 7.7. South America Personalized Cell Therapy Market
  7.7.1 Key Market Trends, Growth Factors and Opportunities
  7.7.2 Top Key Companies
  7.7.3 Historic and Forecasted Market Size by Segments
  7.7.4 Historic and Forecasted Market Size By Cell Type
  7.7.4.1 Embryonic Stem Cells
  7.7.4.2 Adult Stem Cell
  7.7.4.3 Induced Pluripotent Cells
  7.7.4.4 Others
  7.7.5 Historic and Forecasted Market Size By Application
  7.7.5.1 Cardiovascular Diseases
  7.7.5.2 Neurological Disorders
  7.7.5.3 Diabetes
  7.7.5.4 Oncology
  7.7.5.5 Others)
  7.7.5.6 By End User(Hospitals
  7.7.5.7 Homecare
  7.7.5.8 Specialty Clinics
  7.7.5.9 Others)
  7.7.5.10 By Distribution Channel(Hospital Pharmacy
  7.7.5.11 Online Pharmacy
  7.7.5.12 Retail Pharmacy
  7.7.6 Historic and Forecast Market Size by Country
  7.7.6.1 Brazil
  7.7.6.2 Argentina
  7.7.6.3 Rest of SA

Chapter 8 Analyst Viewpoint and Conclusion
8.1 Recommendations and Concluding Analysis
8.2 Potential Market Strategies

Chapter 9 Research Methodology
9.1 Research Process
9.2 Primary Research
9.3 Secondary Research