Trypsin Market - Latest Advancement & Future Trends (2024-2032)

Trypsin Market Synopsis:

Trypsin Market Size Was Valued at USD 96.2 Million in 2023, and is Projected to Reach USD 142.5 Million by 2032, Growing at a CAGR of 5.4 % From 2024-2032.

The trypsin market is the world market, which encompasses demand and supply of trypsin which is a proteolytic enzyme with a wide application in biotechnology, in the pharma industry, in food industry and for research purposes. Exclusively of pancreatic origin, trypsin is useful for cell harvesting, proteolysis and cell dissolution rendering it significantly valuable in biopharmaceutical industries, drug and gene development as well as genomics. Muscle and meat tissue: PAP is also used extensively in the meat tenderization industry and for the preparation of protein hydrolysates for use in foods. It is identified by key megatrends such as advance in biotechnology, pharmaceuticals and emergence of new economies, coupled with rising demand for plant and microbial based trypsin substitutes. However, there is an ethical question about the use of animal-derived trypsin and, therefore, it may face limitation within markets.

In terms of growth, the market shows a stable rate in the sales of trypsin, this attribute can be attributed to the high demand of proteolytic enzymes especially trypsin in biotechnology, pharmaceutical industries and food processing. Pancreatic trypsin obtained hitherto exclusively from bovine and porcine sources remains crucial in several cell culture processes wherein the enzyme is employed for cell dispersion to produce biopharmaceuticals as well as gene therapies and vaccines. It is also used in the synthesis of insulin and other biotherapeutic proteins, and as such is an important component in the biotechnology industry today. When proteomics, genomics and the field of discovering new drugs is growing rapidly then the demand for high quality enzymes including trypsin in research and clinical laboratory is on the rise. Also, to the trypsin-based applications in food processing especially in the tenderizing of meat, production of protein hydrolysates and the preparation of functional foods, the food industry is increasing the market growth.

The market is identified with growing demand in new establishments in emerging economies due to biotechnology, health and food industries that are rapidly developing. The availability of microbial or plant source derived trypsin rather than animal derived seems to have an impact on the market in view of ethical issues and sustainability. Despite the fact that animal derived trypsin has wider application, microbial and recombinant type trypsins are increasing gradually due to its cost effectiveness, low risk of contamination and ethical points of view. However, some threats to this market include; regulatory restraints such as controls placed on the use of animal derived enzymes especially in some parts of the world. It can be expected that the trypsin market will expand further due to advancements in biotechnologies and methods of enzymes production as well as the third-party production sustainability indicators.

Trypsin Market Trend Analysis:

Rising Demand in Biotechnology and Drug Development Fuels Need for High-Quality

• The demand for high-quality trypsin is rapidly increasing across the biotechnology and pharmaceutical industries, driven by its critical role in cell culture, protein production, and the development of new medications. Trypsin is indispensable for cell dissociation, a fundamental process in biopharmaceutical manufacturing, especially in cell-based therapies, gene therapies, and the production of therapeutic proteins like insulin and vaccines. As the global focus shifts toward personalized medicine and biologic products, the need for efficient and reliable enzymes is intensifying.
• The rise of genomic research, proteomics, and precision medicine is expanding trypsin’s applications in drug discovery, preclinical studies, and clinical trials. With the growing pipeline of biologic drugs in oncology, immunotherapy, and rare diseases, trypsin's importance continues to surge. Innovations such as biosimilars and gene-editing technologies like CRISPR further underscore its relevance. The trypsin market is poised for significant growth, supporting the expanding landscape of biotechnology and pharmaceutical research and production.

Growing Demand for Recombinant and Microbial-Derived Trypsin Opens New Market

• The trypsin market is undergoing a major shift driven by the increasing demand for recombinant and microbial-sourced trypsin. Ethical concerns over animal-derived products, combined with a global emphasis on sustainability, are pushing industries toward safer, purer, and more consistent alternatives. Recombinant trypsin, produced through genetically engineered microorganisms, offers higher purity, reduced contamination risk, and stable quality compared to traditional sources.
• Microbial-derived trypsin from bacteria or fungi provides an ethical, eco-friendly solution aligned with sustainability goals in biotechnology, pharmaceuticals, and food technology. This trend is creating significant opportunities for companies to invest in advanced production technologies and meet the rising demand from sensitive industries such as biopharmaceuticals, where recombinant trypsin is crucial in cell culture, protein production, and gene therapy. With increasing regulatory pressure on animal-origin products, microbial enzymes are gaining a competitive edge, driving market growth and positioning innovative suppliers to capitalize on this evolving landscape.

Trypsin Market Segment Analysis:

Trypsin Market is Segmented on the basis of Type, Application, End User, and Region.

By Type, Bovine segment is expected to dominate the market during the forecast period

• The bovine segment is expected to retain the largest share of the global trypsin market throughout the forecast period, driven by its versatile applications in biotechnology, pharmaceuticals, and food industries. Bovine-derived trypsin, known for its high purity, reliability, and cost-effectiveness, is crucial in cell culture, protein production, biopharmaceutical processing, and gene therapy. It efficiently dissociates cells without damaging cellular structures, making it ideal for producing biologics, monoclonal antibodies, and therapeutic proteins.
• Rising interest in biotechnology, personalized medicines, and biologics continues to boost demand. Although microbial and recombinant trypsin alternatives are emerging as more sustainable options, bovine trypsin remains dominant due to its established role, consistent quality, and affordability. In the food sector, it is indispensable for meat tenderization and the production of protein hydrolysates used in functional foods. Expanding food processing technologies and increasing protein consumption globally further sustain its demand, especially in emerging economies where biopharmaceutical markets are rapidly developing.

By Application, Biotechnology segment expected to held the largest share

• The biotechnology sector is projected to remain the largest consumer of trypsin in the coming years, driven by its critical role in various biotechnological processes. Trypsin is essential for cell dissociation and cell harvesting key steps in the development and production of monoclonal antibodies, therapeutic proteins, gene therapies, and vaccines. As biotechnology advances, particularly in biologics, gene editing, and cell therapies, the demand for trypsin is expected to grow significantly.
• The rise of personalized medicine and further biomolecular advancements in the biomedical and biopharmaceutical sectors are strengthening trypsin’s importance. The enzyme improves cell management and boosts the productivity and quality of biologic drugs, making it indispensable for biopharmaceutical manufacturing. With the increasing number of biopharmaceutical and biotech companies focusing on targeted therapies and advanced drug formulations, the biotechnology sector’s reliance on trypsin will continue to solidify, ensuring its dominance in the global trypsin market in the foreseeable future.

Trypsin Market Regional Insights:

North America is Expected to Dominate the Market Over the Forecast period

• North America is projected to dominate the global trypsin market over the forecast period, driven by rapid advancements in biotechnology, pharmaceuticals, and food production. The region hosts leading pharmaceutical companies, biotech firms, and research institutions, fueling trypsin demand for applications such as protein synthesis, cell culture, gene therapy, and biopharmaceutical manufacturing. With the growing focus on biologics, monoclonal antibodies, and gene therapies, the need for high-quality trypsin, particularly for cell dissociation and protein digestion, continues to rise.
• The pharmaceutical industry's emphasis on personalized medicine and advanced drug therapies further accelerates trypsin usage in preclinical and clinical research. North America benefits from a strong healthcare infrastructure, substantial R&D investments, and favorable regulatory frameworks that encourage biotech innovation. Major market players such as Abbott Laboratories, Thermo Fisher Scientific, and Sigma-Aldrich ensure a stable supply of high-quality trypsin. Rising cross-border biomanufacturing and increased biologic drug production further strengthen North America's leadership in the global trypsin market.

Active Key Players in the Trypsin Market

• Abbott Laboratories (USA)
• BASF SE (Germany)
• Biocrick (China)
• Bio-Techne Corporation (USA)
• Creative Enzymes (USA)
• Eppendorf AG (Germany)
• G-Biosciences (USA)
• Jiangsu Suyin Medical Devices Co., Ltd. (China)
• Lonza Group (Switzerland)
• MP Biomedicals (USA)
• New England Biolabs, Inc. (USA)
• Novozymes A/S [Denmark]
• Pancreatic Enzyme Co., Inc. (USA)
• Shandong Xinhua Pharmaceutical Company (China)
• Sigma-Aldrich (Merck Group) (USA)
• Thermo Fisher Scientific Inc. (USA)
• VWR International (USA)
• Wako Pure Chemical Industries Ltd. (Japan)
• Other Active Players.