Downstream Processing Market Synopsis

Downstream Processing Market Size Was Valued at USD  28.42 Billion in 2023, and is Projected to Reach USD  103.15 Billion by 2032, Growing at a CAGR of 15.40% From 2024-2032.

Downstream processing is the process of harvesting and purifying biosynthetic products such as; proteins and antibodies from natural sources or a biological manufacturing process. They embody various phases as the process of separation, purification, and formulation of the compound to reach the final stage of commercial readiness.

• Downstream processing market is one of the most significant segments of biomanufacturing, whereby any drug or biologic, including vaccines, antibodies, hormones, and enzymes, should be produced. The increasing use of biologics and biosimilars creates the need for the advancement of upstream and downstream bioprocessing equipment and techniques for purity and compliance. This market has been emerged by the improvement of technology in the filed of biopharmaceuticals and the prevalence of chronic diseases. Organizations are eventually coming up with newer and improved methods of filtration, chromatography and centrifugation in order to cater for the increasing need and demand for high through-put and cheaper techniques.
• The downstream processing market has been observed to be growing over the past couple of years, especially by biopharmaceutical players and CMOs. These firms are seeking ways and means to improve the production capabilities to meet increasing market for biologics, gene therapies and vaccines. Implementation of ML in downstream processing technologies and enhancing the automation of downstream processing are expected to increase operational effectiveness and optimize production processes by minimizing…the occurrence of human mistake and completing production timelines swiftly. Alongside, some of the government policies and incentives driving the production of biopharmaceutical market will also help the market to grow in the forecast period.

Downstream Processing Market Trend Analysis

Integration of Automation in Downstream Processing

• The market of downstream processing has rapidly experienced the trend of automation. There are new trends in the development of automating the process like chromatography, filtration, and drying are being handled through the automation systems of various firms. Automating a reaction decreases the chance of human error, increases the consistency and the ability to observe multiple reactions and parameters as they are occurring, such as temperature, rate of flow, pressure, etc.
• The continuous application of machine learning, artificial intelligence (AI) is also improving downstream processing to increase efficiency and product yield. These technologies offer forecasts that help to fine-tune other actualization factors, lessening expenditure while maintaining product quality. This trend is especially significant in largescale biopharmaceutical manufacturing, where process availability and productivity are paramount to capacity.

Growing Demand for Monoclonal Antibodies

• Interestingly, conditions like cancer and autoimmune diseases have become more rampant, giving favorable market conditions for the downstream processing of monoclonal antibodies. The miraculous aspect of targeted therapies is that monoclonal antibodies are specific and do not have side effects as worse as the conventional remedies.
• High value downstream processing advancements are sought to improve the efficiency, purity, and return of monoclonal antibodies. Manufacturers are spending on and demanding enhanced chromatography systems and filteration solutions to deliver the high quality of monoclonal antibody. The increasing market demand for biologics creates opportunities for players in the market to establish new ways to enhance the efficiency, scalability, and reduced costs of mAb production.

Downstream Processing Market Segment Analysis:

Downstream Processing Market Segmented based on  Product , Application, and Technique.

By   Product , Dryers segment is expected to dominate the market during the forecast period

• The downstream processing market is classified broadly into product types such as centrifuges, dryers, chromatography systems, filters, evaporators, and other downstream processing systems. Centrifuges are required in the separation of biological constituents by their specific mass and volume. They are industry standard in the biopharmaceutical application for concentration of cell cultures and harvests. While chromatography systems on the hand help in the purification of protein, antibodies and all biomolecules, they are very essential in biomanufacturing.
• Precoat filters and dryers are also considered downstream processing equipment. These filters serve a purpose of clarification and sterilizing fluids before final formulation to have a clean record of contaminants free. Dryers are employed to reduce the level of moisture in biomolecules in order to have a stable structure to facilitate storage and transport of the biomolecules. A growing demand for separator-based biopharmaceuticals creates demand for sophisticated high-value downstream processing systems that fuel this segment.

By Application , Hormone Production segment held the largest share in 2023

• Downstream processing has many uses in production of antibodies, antibiotics, hormones, enzymes and vaccines. Monoclonal antibodies are substantially used for treatment of cancer, autoimmune, and infectious diseases; therefore, antibody production occupies one of the leading positions among the large application segments. Methods of purification such as filtration, chromatography and centrifugation are important in realizing high levels of purity required for therapeutic antibodies.
• In the same way, the production of vaccines has grown especially due to the current coronavirus outbreak. The requirement for viable downstream processing solutions has become increasingly important for pharma firms as the world requires vaccines. end-user processes such as formulation and purification, are equally important in ensuring vaccine safety and efficacy; therefore, provide impetus to this application segment.

Downstream Processing Market Regional Insights:

North America is Expected to Dominate the Market Over the Forecast period

• Currently, North America is leading the downstream processing market because of its stronger biopharmaceutical industry and vigorous Research and Development initiatives. Downstream processing equipments are widely used in the biotechnological applications by many key industry players which include many biotechnology and pharmaceutical firms in the region. The access to good number of healthcare amenities and high health care spend also aiding North America to have commanding position in this market.
• Furthermore, the increasing importance of biotherapeutics such as biologics, biosimilars and advanced therapies including the personalized medicines in the United States of America and Canada has again created high demand for efficient downstream processing. Government policies and updated policies towards biopharmaceutical manufacturing have also significantly contributed towards growth of this market in this region.

Active Key Players in the Downstream Processing Market

• Danaher Corporation (USA)
• Merck KGaA (Germany)
• Sartorius AG (Germany)
• Thermo Fisher Scientific, Inc. (USA)
• General Electric (GE Healthcare) (USA)
• 3M Company (USA)
• Repligen Corporation (USA)
• Eppendorf AG (Germany)
• Boehringer Ingelheim (Germany)
• Lonza Group (Switzerland)
• Asahi Kasei Corporation (Japan)
• Corning Inc. (USA)
• Novasep (France)
• Fujifilm Diosynth Biotechnologies (Japan)
• Hitachi Koki Co., Ltd. (Japan), Other Active Players

Key Industry Developments in the Downstream Processing Market

• In April 2022, Thermo Fisher Scientific opened a bioprocessing manufacturing site in Ogden, Utah, for the development of biologics and vaccines.
• In May 2022, Sartorius began focusing on the growth of its global production capacity with the expansion of its manufacturing site in Tunisia.
• In June 2022, Bio-Rad introduced the CHT™ prepacked Foresight Pro Columns in order to serve downstream process-scale chromatography applications throughout all stages of biological drug research and manufacture.

Chapter 1: Introduction
 1.1 Scope and Coverage

Chapter 2:Executive Summary

Chapter 3: Market Landscape
 3.1 Market Dynamics
  3.1.1 Drivers
  3.1.2 Restraints
  3.1.3 Opportunities
  3.1.4 Challenges
 3.2 Market Trend Analysis
 3.3 PESTLE Analysis
 3.4 Porter's Five Forces Analysis
 3.5 Industry Value Chain Analysis
 3.6 Ecosystem
 3.7 Regulatory Landscape
 3.8 Price Trend Analysis
 3.9 Patent Analysis
 3.10 Technology Evolution
 3.11 Investment Pockets
 3.12 Import-Export Analysis

Chapter 4: Downstream Processing Market by Product
 4.1 Downstream Processing Market Snapshot and Growth Engine
 4.2 Downstream Processing Market Overview
 4.3 Centrifuges
  4.3.1 Introduction and Market Overview
  4.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.3.3 Key Market Trends, Growth Factors and Opportunities
  4.3.4 Centrifuges: Geographic Segmentation Analysis
 4.4 Dryers
  4.4.1 Introduction and Market Overview
  4.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.4.3 Key Market Trends, Growth Factors and Opportunities
  4.4.4 Dryers: Geographic Segmentation Analysis
 4.5 Chromatography Systems
  4.5.1 Introduction and Market Overview
  4.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.5.3 Key Market Trends, Growth Factors and Opportunities
  4.5.4 Chromatography Systems: Geographic Segmentation Analysis
 4.6 Filters
  4.6.1 Introduction and Market Overview
  4.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.6.3 Key Market Trends, Growth Factors and Opportunities
  4.6.4 Filters: Geographic Segmentation Analysis
 4.7 Evaporators
  4.7.1 Introduction and Market Overview
  4.7.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.7.3 Key Market Trends, Growth Factors and Opportunities
  4.7.4 Evaporators: Geographic Segmentation Analysis
 4.8 Others
  4.8.1 Introduction and Market Overview
  4.8.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  4.8.3 Key Market Trends, Growth Factors and Opportunities
  4.8.4 Others: Geographic Segmentation Analysis

Chapter 5: Downstream Processing Market by Application
 5.1 Downstream Processing Market Snapshot and Growth Engine
 5.2 Downstream Processing Market Overview
 5.3 Antibodies Production
  5.3.1 Introduction and Market Overview
  5.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.3.3 Key Market Trends, Growth Factors and Opportunities
  5.3.4 Antibodies Production: Geographic Segmentation Analysis
 5.4 Antibiotic Production
  5.4.1 Introduction and Market Overview
  5.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.4.3 Key Market Trends, Growth Factors and Opportunities
  5.4.4 Antibiotic Production: Geographic Segmentation Analysis
 5.5 Hormone Production
  5.5.1 Introduction and Market Overview
  5.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.5.3 Key Market Trends, Growth Factors and Opportunities
  5.5.4 Hormone Production: Geographic Segmentation Analysis
 5.6 Enzyme Production
  5.6.1 Introduction and Market Overview
  5.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.6.3 Key Market Trends, Growth Factors and Opportunities
  5.6.4 Enzyme Production: Geographic Segmentation Analysis
 5.7 Vaccine Production
  5.7.1 Introduction and Market Overview
  5.7.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  5.7.3 Key Market Trends, Growth Factors and Opportunities
  5.7.4 Vaccine Production: Geographic Segmentation Analysis

Chapter 6: Downstream Processing Market by Technique
 6.1 Downstream Processing Market Snapshot and Growth Engine
 6.2 Downstream Processing Market Overview
 6.3 Purification by Chromatography
  6.3.1 Introduction and Market Overview
  6.3.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.3.3 Key Market Trends, Growth Factors and Opportunities
  6.3.4 Purification by Chromatography: Geographic Segmentation Analysis
 6.4 Solid-liquid Separation
  6.4.1 Introduction and Market Overview
  6.4.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.4.3 Key Market Trends, Growth Factors and Opportunities
  6.4.4 Solid-liquid Separation: Geographic Segmentation Analysis
 6.5 Cell Disruption
  6.5.1 Introduction and Market Overview
  6.5.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.5.3 Key Market Trends, Growth Factors and Opportunities
  6.5.4 Cell Disruption: Geographic Segmentation Analysis
 6.6 Concentration
  6.6.1 Introduction and Market Overview
  6.6.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.6.3 Key Market Trends, Growth Factors and Opportunities
  6.6.4 Concentration: Geographic Segmentation Analysis
 6.7 Formulation
  6.7.1 Introduction and Market Overview
  6.7.2 Historic and Forecasted Market Size in Value USD and Volume Units (2017-2032F)
  6.7.3 Key Market Trends, Growth Factors and Opportunities
  6.7.4 Formulation: Geographic Segmentation Analysis

Chapter 7: Company Profiles and Competitive Analysis
 7.1 Competitive Landscape
  7.1.1 Competitive Benchmarking
  7.1.2 Downstream Processing Market Share by Manufacturer (2023)
  7.1.3 Industry BCG Matrix
  7.1.4 Heat Map Analysis
  7.1.5 Mergers and Acquisitions
  
 7.2 DANAHER CORPORATION (USA)
  7.2.1 Company Overview
  7.2.2 Key Executives
  7.2.3 Company Snapshot
  7.2.4 Role of the Company in the Market
  7.2.5 Sustainability and Social Responsibility
  7.2.6 Operating Business Segments
  7.2.7 Product Portfolio
  7.2.8 Business Performance
  7.2.9 Key Strategic Moves and Recent Developments
  7.2.10 SWOT Analysis
 7.3 MERCK KGAA (GERMANY)
 7.4 SARTORIUS AG (GERMANY)
 7.5 THERMO FISHER SCIENTIFIC INC (USA)
 7.6 GENERAL ELECTRIC (GE HEALTHCARE) (USA)
 7.7 3M COMPANY (USA)
 7.8 REPLIGEN CORPORATION (USA)
 7.9 EPPENDORF AG (GERMANY)
 7.10 BOEHRINGER INGELHEIM (GERMANY)
 7.11 LONZA GROUP (SWITZERLAND)
 7.12 ASAHI KASEI CORPORATION (JAPAN)
 7.13 CORNING INC. (USA)
 7.14 NOVASEP (FRANCE)
 7.15 FUJIFILM DIOSYNTH BIOTECHNOLOGIES (JAPAN)
 7.16 HITACHI KOKI CO LTD (JAPAN)
 7.17 OTHER ACTIVE PLAYERS

Chapter 8: Global Downstream Processing Market By Region
 8.1 Overview
 8.2. North America Downstream Processing Market
  8.2.1 Key Market Trends, Growth Factors and Opportunities
  8.2.2 Top Key Companies
  8.2.3 Historic and Forecasted Market Size by Segments
  8.2.4 Historic and Forecasted Market Size By Product
  8.2.4.1 Centrifuges
  8.2.4.2 Dryers
  8.2.4.3 Chromatography Systems
  8.2.4.4 Filters
  8.2.4.5 Evaporators
  8.2.4.6 Others
  8.2.5 Historic and Forecasted Market Size By Application
  8.2.5.1 Antibodies Production
  8.2.5.2 Antibiotic Production
  8.2.5.3 Hormone Production
  8.2.5.4 Enzyme Production
  8.2.5.5 Vaccine Production
  8.2.6 Historic and Forecasted Market Size By Technique
  8.2.6.1 Purification by Chromatography
  8.2.6.2 Solid-liquid Separation
  8.2.6.3 Cell Disruption
  8.2.6.4 Concentration
  8.2.6.5 Formulation
  8.2.7 Historic and Forecast Market Size by Country
  8.2.7.1 US
  8.2.7.2 Canada
  8.2.7.3 Mexico
 8.3. Eastern Europe Downstream Processing Market
  8.3.1 Key Market Trends, Growth Factors and Opportunities
  8.3.2 Top Key Companies
  8.3.3 Historic and Forecasted Market Size by Segments
  8.3.4 Historic and Forecasted Market Size By Product
  8.3.4.1 Centrifuges
  8.3.4.2 Dryers
  8.3.4.3 Chromatography Systems
  8.3.4.4 Filters
  8.3.4.5 Evaporators
  8.3.4.6 Others
  8.3.5 Historic and Forecasted Market Size By Application
  8.3.5.1 Antibodies Production
  8.3.5.2 Antibiotic Production
  8.3.5.3 Hormone Production
  8.3.5.4 Enzyme Production
  8.3.5.5 Vaccine Production
  8.3.6 Historic and Forecasted Market Size By Technique
  8.3.6.1 Purification by Chromatography
  8.3.6.2 Solid-liquid Separation
  8.3.6.3 Cell Disruption
  8.3.6.4 Concentration
  8.3.6.5 Formulation
  8.3.7 Historic and Forecast Market Size by Country
  8.3.7.1 Bulgaria
  8.3.7.2 The Czech Republic
  8.3.7.3 Hungary
  8.3.7.4 Poland
  8.3.7.5 Romania
  8.3.7.6 Rest of Eastern Europe
 8.4. Western Europe Downstream Processing Market
  8.4.1 Key Market Trends, Growth Factors and Opportunities
  8.4.2 Top Key Companies
  8.4.3 Historic and Forecasted Market Size by Segments
  8.4.4 Historic and Forecasted Market Size By Product
  8.4.4.1 Centrifuges
  8.4.4.2 Dryers
  8.4.4.3 Chromatography Systems
  8.4.4.4 Filters
  8.4.4.5 Evaporators
  8.4.4.6 Others
  8.4.5 Historic and Forecasted Market Size By Application
  8.4.5.1 Antibodies Production
  8.4.5.2 Antibiotic Production
  8.4.5.3 Hormone Production
  8.4.5.4 Enzyme Production
  8.4.5.5 Vaccine Production
  8.4.6 Historic and Forecasted Market Size By Technique
  8.4.6.1 Purification by Chromatography
  8.4.6.2 Solid-liquid Separation
  8.4.6.3 Cell Disruption
  8.4.6.4 Concentration
  8.4.6.5 Formulation
  8.4.7 Historic and Forecast Market Size by Country
  8.4.7.1 Germany
  8.4.7.2 UK
  8.4.7.3 France
  8.4.7.4 Netherlands
  8.4.7.5 Italy
  8.4.7.6 Russia
  8.4.7.7 Spain
  8.4.7.8 Rest of Western Europe
 8.5. Asia Pacific Downstream Processing Market
  8.5.1 Key Market Trends, Growth Factors and Opportunities
  8.5.2 Top Key Companies
  8.5.3 Historic and Forecasted Market Size by Segments
  8.5.4 Historic and Forecasted Market Size By Product
  8.5.4.1 Centrifuges
  8.5.4.2 Dryers
  8.5.4.3 Chromatography Systems
  8.5.4.4 Filters
  8.5.4.5 Evaporators
  8.5.4.6 Others
  8.5.5 Historic and Forecasted Market Size By Application
  8.5.5.1 Antibodies Production
  8.5.5.2 Antibiotic Production
  8.5.5.3 Hormone Production
  8.5.5.4 Enzyme Production
  8.5.5.5 Vaccine Production
  8.5.6 Historic and Forecasted Market Size By Technique
  8.5.6.1 Purification by Chromatography
  8.5.6.2 Solid-liquid Separation
  8.5.6.3 Cell Disruption
  8.5.6.4 Concentration
  8.5.6.5 Formulation
  8.5.7 Historic and Forecast Market Size by Country
  8.5.7.1 China
  8.5.7.2 India
  8.5.7.3 Japan
  8.5.7.4 South Korea
  8.5.7.5 Malaysia
  8.5.7.6 Thailand
  8.5.7.7 Vietnam
  8.5.7.8 The Philippines
  8.5.7.9 Australia
  8.5.7.10 New Zealand
  8.5.7.11 Rest of APAC
 8.6. Middle East & Africa Downstream Processing Market
  8.6.1 Key Market Trends, Growth Factors and Opportunities
  8.6.2 Top Key Companies
  8.6.3 Historic and Forecasted Market Size by Segments
  8.6.4 Historic and Forecasted Market Size By Product
  8.6.4.1 Centrifuges
  8.6.4.2 Dryers
  8.6.4.3 Chromatography Systems
  8.6.4.4 Filters
  8.6.4.5 Evaporators
  8.6.4.6 Others
  8.6.5 Historic and Forecasted Market Size By Application
  8.6.5.1 Antibodies Production
  8.6.5.2 Antibiotic Production
  8.6.5.3 Hormone Production
  8.6.5.4 Enzyme Production
  8.6.5.5 Vaccine Production
  8.6.6 Historic and Forecasted Market Size By Technique
  8.6.6.1 Purification by Chromatography
  8.6.6.2 Solid-liquid Separation
  8.6.6.3 Cell Disruption
  8.6.6.4 Concentration
  8.6.6.5 Formulation
  8.6.7 Historic and Forecast Market Size by Country
  8.6.7.1 Turkey
  8.6.7.2 Bahrain
  8.6.7.3 Kuwait
  8.6.7.4 Saudi Arabia
  8.6.7.5 Qatar
  8.6.7.6 UAE
  8.6.7.7 Israel
  8.6.7.8 South Africa
 8.7. South America Downstream Processing Market
  8.7.1 Key Market Trends, Growth Factors and Opportunities
  8.7.2 Top Key Companies
  8.7.3 Historic and Forecasted Market Size by Segments
  8.7.4 Historic and Forecasted Market Size By Product
  8.7.4.1 Centrifuges
  8.7.4.2 Dryers
  8.7.4.3 Chromatography Systems
  8.7.4.4 Filters
  8.7.4.5 Evaporators
  8.7.4.6 Others
  8.7.5 Historic and Forecasted Market Size By Application
  8.7.5.1 Antibodies Production
  8.7.5.2 Antibiotic Production
  8.7.5.3 Hormone Production
  8.7.5.4 Enzyme Production
  8.7.5.5 Vaccine Production
  8.7.6 Historic and Forecasted Market Size By Technique
  8.7.6.1 Purification by Chromatography
  8.7.6.2 Solid-liquid Separation
  8.7.6.3 Cell Disruption
  8.7.6.4 Concentration
  8.7.6.5 Formulation
  8.7.7 Historic and Forecast Market Size by Country
  8.7.7.1 Brazil
  8.7.7.2 Argentina
  8.7.7.3 Rest of SA

Chapter 9 Analyst Viewpoint and Conclusion
9.1 Recommendations and Concluding Analysis
9.2 Potential Market Strategies

Chapter 10 Research Methodology
10.1 Research Process
10.2 Primary Research
10.3 Secondary Research